Since 1963, the Anniston Academy - later named The Donoho School after Mrs. Harriet Donoho - has expanded into the premier institution of primary and secondary education in Northeast Alabama and is recognized for its excellence throughout the nation. Founded as a secondary institution in 1963 and chartered under the name of The Anniston Academy, the school has enjoyed a healthy expansion to meet the growing needs of the community it serves. In 1976 the name was changed to The Donoho School in recognition of Mrs. Harriet Wallis Donoho, a founder and benefactor of the school.

The present Lower Division was founded as The Episcopal Day School in 1961 as an independent elementary school. Housed originally in the facilities of the Church of St. Michael and All Angels, the school moved into Grace Episcopal Church in 1967.

In the summer of 1976, The Episcopal Day School merged with The Donoho School and became the Lower Division. In 1980 the Lower and Middle Divisions moved into a new facility constructed on the Donoho campus and The Donoho Upper School divided to become a Middle Division comprised of grades seven and eight and an Upper Division of grades nine through twelve.

In 1989, the Middle Division moved into a new facility constructed adjacent to the Upper Division. This expansion allowed the school to offer two sections per grade in kindergarten through grade twelve. Further additions have been made to the early childhood program with the introduction of a PK4 program.