The Donoho School features a challenging academic curriculum within a family environment and opportunities for all students to participate in athletics, the performing arts, and a wide array of other co and extra-curricular activities. The academic program is aimed at providing the best possible college preparatory education for average to above-average students who have demonstrated an interest, willingness and ability to learn in their previous school environments. Students at the high school level benefit from options to engage in honors, accelerated, and Advanced Placement course electives in all the major disciplines in preparation for their enrollment in some of the nation's top colleges and universities.

Each member of the faculty serves in a mentor/advisor role that is considered by the school as equal in importance to that of his or her teaching contribution in the classroom. The school's curriculum emphasizes maximizing effective student/teacher/parent communications in a student-centered learning environment in all three divisions

Peer tutorial, religion class, math and science Olympiad teams, and a school newspaper are some of the activities provided at the Intermediate Division. The Middle Division offers language arts team, quiz bowl team, and leadership opportunities in the Student Government Association. At the High School Division, special interest clubs are available in drama, science, math, French, Spanish, and computer science. National honorary groups include Mu Alpha Theta (math), National Honor Society, and the National French Honor Society. Knox Concert Series Service Club, SAAD, Interact and Hi-Y are examples of service-oriented organizations available. Students showing an interest in journalistic endeavors produce the school annual (Gauntlet), the school newspaper (The Pen Feather), and an art literary magazine (The Lure). Leadership opportunities are available through the Student Government Association and the Honor Council.